Search results for "REACTION-TIME PERFORMANCE"

showing 2 items of 2 documents

A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and sibli…

2011

Item does not contain fulltext BACKGROUND: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotonin-regulating genes. METHODS: Impulsive drive for immediate reward and delay aversion were measured in 459 male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonin-transporter-linked polymorphic region polymorphism and a …

DEFICIT HYPERACTIVITY DISORDERMedizinSocial Sciencesimpulsivity610 Medicine & healthCHILDRENSingle-nucleotide polymorphismGenomic disorders and inherited multi-system disorders Functional Neurogenomics [IGMD 3]attention-deficit/hyperactivity disorderImpulsivityCOMBINED-TYPE ADHDREACTION-TIME PERFORMANCEDevelopmental psychologyGenomic disorders and inherited multi-system disorders [IGMD 3]DOPAMINE03 medical and health sciences0302 clinical medicineDopaminemedicineAttention deficit hyperactivity disorderddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersAlleleBiological PsychiatrySerotonin transporter030304 developmental biologyDopamine transporterGeneticsMental Health [NCEBP 9]0303 health sciencesDELAY AVERSIONbiologyTRYPTOPHAN DEPLETIONASSOCIATION10058 Department of Child and Adolescent Psychiatrymedicine.diseasePOLYMORPHISM5-HTTLPR (SLC6A4)5-HTTLPRbiology.proteinCRITERION VALIDITYmedicine.symptomDAT1 (SLC6A3)Psychology2803 Biological PsychiatryFunctional Neurogenomics [DCN 2]030217 neurology & neurosurgerymedicine.drugBiological Psychiatry
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Separation of Cognitive Impairments in Attention-Deficit/Hyperactivity Disorder Into 2 Familial Factors

2010

Contains fulltext : 89304.pdf (Publisher’s version ) (Open Access) CONTEXT: Attention-deficit/hyperactivity disorder (ADHD) is associated with widespread cognitive impairments, but it is not known whether the apparent multiple impairments share etiological roots or separate etiological pathways exist. A better understanding of the etiological pathways is important for the development of targeted interventions and for identification of suitable intermediate phenotypes for molecular genetic investigations. OBJECTIVES: To determine, by using a multivariate familial factor analysis approach, whether 1 or more familial factors underlie the slow and variable reaction times, impaired response inhi…

ProbandMaleMedizinComorbidityNeuropsychological TestsChoice BehaviorDevelopmental psychology2738 Psychiatry and Mental HealthMOLECULAR-GENETICS0302 clinical medicinePerception and Action [DCN 1]GENETIC INFLUENCES10. No inequalityChildMental Health [NCEBP 9]Cognitive disorderCognition10058 Department of Child and Adolescent PsychiatryPedigreePsychiatry and Mental healthPhenotype1201 Arts and Humanities (miscellaneous)Femalemedicine.symptomPsychologyFunctional Neurogenomics [DCN 2]AdolescentDEFICIT HYPERACTIVITY DISORDERContext (language use)610 Medicine & healthImpulsivityArticleREACTION-TIME PERFORMANCE03 medical and health sciencesArts and Humanities (miscellaneous)medicineReaction TimeAttention deficit hyperactivity disorderHumansINTRA-SUBJECT VARIABILITYFamilyINHIBITORY CONTROLGENOME-WIDE ASSOCIATIONDELAY AVERSIONSiblingsSocial environmentmedicine.diseaseComorbidity030227 psychiatryAttention Deficit Disorder with HyperactivityImpulsive BehaviorRESPONSE VARIABILITYSUSTAINED ATTENTIONCognition DisordersFactor Analysis Statistical030217 neurology & neurosurgery
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